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Keywords:

  • bioinorganic chemistry;
  • heme proteins;
  • iron;
  • ligand affinity;
  • structural biology
Thumbnail image of graphical abstract

O2balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).