Particularly enriching: Core–shell–shell Fe3O4§SiO2§PMMA composite microspheres (see picture; PMMA=poly(methyl methacrylate)) were synthesized readily by combining a sol-gel approach with a seeded aqueous-phase radical polymerization method. The microspheres were successfully applied toward the effective, rapid, and convenient enrichment of low-concentration peptides and proteins for mass spectrometric analysis.
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