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Keywords:

  • β-amyloid peptides;
  • islet amyloid polypeptides;
  • molecular recognition;
  • protein interactions;
  • protein self-assembly
Thumbnail image of graphical abstract

Short peptide sequences are identified as hot regions of the cross-interaction interface of the Alzheimer's disease β-amyloid peptide (Aβ) with the type 2 diabetes islet amyloid polypeptide (IAPP). They are shown to be high-affinity ligands of both Aβ and IAPP, thus suggesting common molecular recognition features in amyloid self- and cross-amyloid hetero-assembly.