Asymmetric Synthesis of Chiral Silacarboxylic Acids and Their Ester Derivatives


  • This research was supported in part by a Grant-in-Aid for Scientific Research) (B) No. 19350019 and Global COE Program (Kyushu Univ.) from MEXT (Japan). We thank Y. Tanaka, K. Ideta, and T. Matsumoto (IMCE, Kyushu Univ.) for HRMS measurements, 29Si NMR measurements, and single crystal X-ray diffraction analysis, respectively.


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Sila analogues: The first asymmetric synthesis of silacarboxylic acids with a stereogenic center at the silicon atom has been achieved from chiral nonracemic silanols, without loss of optical purity. Silacarboxylic acids can be converted into their corresponding esters using a Mitsunobu-type reaction.