Communication

Iodinated Nanoscale Coordination Polymers as Potential Contrast Agents for Computed Tomography†

  1. Kathryn E. deKrafft1,
  2. Zhigang Xie Dr.1,
  3. Guohua Cao Dr.2,
  4. Sylvie Tran1,
  5. Liqing Ma Dr.1,
  6. Otto Z. Zhou Prof.2,
  7. Wenbin Lin Prof.1

Article first published online: 24 NOV 2009

DOI: 10.1002/anie.200904958

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 52, pages 9901–9904, December 21, 2009

Additional Information

How to Cite

deKrafft, K., Xie, Z., Cao, G., Tran, S., Ma, L., Zhou, O. and Lin, W. (2009), Iodinated Nanoscale Coordination Polymers as Potential Contrast Agents for Computed Tomography. Angewandte Chemie International Edition, 48: 9901–9904. doi: 10.1002/anie.200904958

Author Information

  1. 1

    Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599 (USA), Fax: (+1) 919-962-2388 http://www.chem.unc.edu/people/faculty/linw/wlindex.html

  2. 2

    Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599 (USA)

  1. †

    We acknowledge financial support from the NIH (U54-CA119343) and the NSF (DMR-0906662).

Publication History

  1. Issue published online: 15 DEC 2009
  2. Article first published online: 24 NOV 2009
  3. Manuscript Revised: 25 OCT 2009
  4. Manuscript Received: 3 SEP 2009

Funded by

  • NIH. Grant Number: U54-CA119343
  • NSF. Grant Number: DMR-0906662

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (532K)

Keywords:

  • computed tomography;
  • contrast agents;
  • coordination polymers;
  • iodine;
  • nanoparticles

Graphical Abstract

Thumbnail image of graphical abstract

Nanoscale coordination polymers (NCPs), prepared with metal ions and an iodinated ligand, were synthesized using reverse-phase microemulsion techniques and rapid precipitation procedures. The NCPs carry high payloads of iodine (ca. 63 wt %) and have potential applications as a new class of contrast agents for computed tomography (CT), as demonstrated by phantom studies (see figure).

View Full Article with Supporting Information (HTML) Get PDF (532K)