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Keywords:

  • 1,3-dipolar cycloaddition;
  • biocompatible ligation;
  • cyclopeptides;
  • peptidomimetics;
  • triazoles
Thumbnail image of graphical abstract

Support and guidance: Azidopeptidyl phosphoranes on a solid support react very efficiently through cyclative cleavage to yield cyclopeptides with an incorporated triazole ring. The solid support is advantageous as cyclization is favored strongly over oligomerization reactions and thus only cyclized products are released.