This work was supported by Grant-in-Aid for Science Research on Priority Areas (No. 18064014, Synergy of Elements) from Ministry of Education, Culture, Sports, Science and Technology (Japan).
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Hydrosilane Reduction of Tertiary Carboxamides by Iron Carbonyl Catalysts†
Article first published online: 10 NOV 2009
DOI: 10.1002/anie.200905025
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Sunada, Y., Kawakami, H., Imaoka, T., Motoyama, Y. and Nagashima, H. (2009), Hydrosilane Reduction of Tertiary Carboxamides by Iron Carbonyl Catalysts. Angew. Chem. Int. Ed., 48: 9511–9514. doi: 10.1002/anie.200905025
- †
Publication History
- Issue published online: 30 NOV 2009
- Article first published online: 10 NOV 2009
- Manuscript Received: 8 SEP 2009
Funded by
- Ministry of Education, Culture, Sports, Science and Technology. Grant Number: 18064014
Keywords:
- amides;
- amines;
- hydrosilanes;
- iron;
- reduction
Fox in the carboxamide: Reduction of tertiary carboxamides to their corresponding amines is catalyzed by [Fe(CO)5] or [Fe3(CO)12], using 1,1,3,3-tetramethyldisiloxane (TMDS) as the reducing agent. The reaction proceeds under either thermal or photochemical conditions. Unlike the hydrosilane reduction of amides using platinum or ruthenium catalysts, TMDS preferentially reduces a nitro group, even in the presence of competing amides.