We thank O. A. Roth and L. Schneider for initial studies and Dr. W. B. Schweizer for X-ray crystallographic analysis of compound 5 j. We gratefully acknowledge ETH Zurich (ETH-16 08-3) and Fonds der Chemischen Industrie (Liebig-Fellowship to N.C.) for funding. We thank Prof. Dr. E. M. Carreira for generous support and Prof. Dr. D. Seebach for helpful discussions.
Enantioselective Palladium-Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters†
Article first published online: 26 OCT 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 48, pages 9139–9142, November 16, 2009
How to Cite
Albicker, Martin R. and Cramer, N. (2009), Enantioselective Palladium-Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters. Angew. Chem. Int. Ed., 48: 9139–9142. doi: 10.1002/anie.200905060
- Issue published online: 11 NOV 2009
- Article first published online: 26 OCT 2009
- Manuscript Received: 9 SEP 2009
- ETH Zurich. Grant Number: ETH-16 08-3
- asymmetric catalysis;
- CH activation;
- direct arylation;
Ta daa: The title reaction proceeds under essentially neutral reaction conditions at ambient temperature with a taddol-based phosphoramidite ligand L* allowing the creation of indanes with quaternary stereogenic centers in high enantiomeric excess (see scheme; Tf=trifluoromethanesulfonyl, DMAc=dimethylacetamide).