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Keywords:

  • biocatalysis;
  • C[BOND]C coupling;
  • Friedel–Crafts alkylation;
  • S-adenosyl-L-methionine;
  • sustainable chemistry
Thumbnail image of graphical abstract

A novel biocatalytic protocol for C[BOND]C bond formation is described and is an equivalent to Friedel–Crafts alkylation. S-Adenosyl-L-methionine (SAM), the major methyl donor for biological methylation catalyzed by methyltransferases (Mtases), can perform alkylations (see scheme). These enzymes can accept non-natural cofactors and transfer functionalities other than methyl onto aromatic substrates.