Wacker-Type Oxidation of Internal Olefins Using a PdCl2/N,N-Dimethylacetamide Catalyst System under Copper-Free Reaction Conditions


  • This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (no. 18065016, “Chemistry of Concerto Catalysis”) from Ministry of Education, Culture, Sports, Science, and Technology (Japan).


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A simple catalyst system consisting of PdCl2 and N,N-dimethylacetamide (DMA) as the solvent can successfully promote Wacker-type oxidation of internal olefins. This catalyst system does not require copper compounds and is tolerant of a wide range of substrates having internal olefins.