J.E.M. acknowledges the EPSRC, ClaxoSmithKline, AICR, and the University of Nottingham for financial support. Special thanks go to Dr. Pallavi Sharma, Dr. Dougal Ritson, Dr. Simon MacDonald, and Steve Keeling.
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Copper-Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles†
Article first published online: 17 NOV 2009
DOI: 10.1002/anie.200905322
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Spiteri, C. and Moses, J. (2010), Copper-Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles. Angewandte Chemie International Edition, 49: 31–33. doi: 10.1002/anie.200905322
- †
Publication History
- Issue published online: 22 DEC 2009
- Article first published online: 17 NOV 2009
- Manuscript Received: 23 SEP 2009
Funded by
- EPSRC
- ClaxoSmithKline
- Abstract
- Article
- References
- Cited By
Keywords:
- azides;
- click chemistry;
- cycloaddition;
- iodoalkynes;
- iodotriazoles
Graphical Abstract
Clicking along nicely: Few methods have been reported to be an efficient entry to trisubstituted triazoles with high regioselectivity. This challenge has inspired a search for new reactivity and the development of new chemical approaches. The development of an efficient, robust, one-pot procedure as a route to highly decorated trisubstituted triazoles will be an added bonus to the range of click reactions (see scheme).