Get access

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes


  • Generous financial support from the National Institutes of Health (GM46059) is gratefully acknowledged. We thank Merck and Boehringer-Ingelheim for additional funds. The Varian 300 MHz used in this work was purchased with funding from the National Institutes of Health (GM 1S10RR13886-01). We are grateful to Dr. David S. Surry (MIT) for initial studies on asymmetric hydroamination process and help in the preparation of the manuscript.


original image

One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities.

Get access to the full text of this article