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Keywords:

  • α-hemolysin;
  • DNA sequencing;
  • nanopores;
  • protein engineering;
  • single-nucleotide analysis
Thumbnail image of graphical abstract

The α-hemolysin nanopore is a promising sensor for ultra-rapid sequencing of DNA strands within nanopores. By using immobilized synthetic oligonucleotides, it is shown that additional sequence information can be gained when two recognition sites, rather than one, are employed within a single nanopore (see picture).