Multiple Base-Recognition Sites in a Biological Nanopore: Two Heads are Better than One


  • This work was supported by grants from the NIH, the MRC, and the European Commission’s seventh Framework Programme (FP7) READNA Consortium. D.S. was supported by a BBSRC Doctoral Training Grant.


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The α-hemolysin nanopore is a promising sensor for ultra-rapid sequencing of DNA strands within nanopores. By using immobilized synthetic oligonucleotides, it is shown that additional sequence information can be gained when two recognition sites, rather than one, are employed within a single nanopore (see picture).