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Keywords:

  • natural products;
  • radical reactions;
  • samarium;
  • total synthesis
Thumbnail image of graphical abstract

Waiting in line: Aldehyde groups take turns reacting in a SmI2-mediated cyclization cascade to form the skeleton 2 of the antibacterial natural product pleuromutilin. Two rings and four contiguous stereocenters are constructed during the cascade with complete diastereocontrol.