Financial support by the European Union (STREP project LSHG-CT-2005-518194), by the European Research Council (ERC starting grant 2008, ZT), and by the Bundesministerium für Bildung und Forschung (BMBF, NGFN project 0313442) is gratefully acknowledged. We thank Tamara Papadakis for preparing the cryosections.
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Communication
Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging†
Article first published online: 15 APR 2010
DOI: 10.1002/anie.200905559
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Römpp, A., Guenther, S., Schober, Y., Schulz, O., Takats, Z., Kummer, W. and Spengler, B. (2010), Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging. Angew. Chem. Int. Ed., 49: 3834–3838. doi: 10.1002/anie.200905559
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Publication History
- Issue published online: 10 MAY 2010
- Article first published online: 15 APR 2010
- Manuscript Revised: 26 JAN 2010
- Manuscript Received: 5 OCT 2009
Funded by
- European Union. Grant Number: LSHG-CT-2005-518194
- European Research Council
- Bundesministerium für Bildung und Forschung. Grant Number: 0313442
Keywords:
- accurate mass;
- histology;
- imaging;
- mass spectrometry;
- spatial resolution
Next-generation imaging mass spectrometry of biological tissue on the cellular level shows excellent agreement with histochemical evaluation whilst providing a much higher discrimination capacity based on label-free molecular information (see image of a mouse urinary bladder section).