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An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection

Authors

  • Zhi Zhu,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-846-2410
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  • Cuichen Wu,

    1. State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
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  • Haipeng Liu,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-846-2410
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  • Yuan Zou,

    1. State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
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  • Xiaoling Zhang Prof.,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-846-2410
    2. Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081 (China)
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  • Huaizhi Kang,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-846-2410
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  • Chaoyong James Yang Prof. Dr.,

    1. State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
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  • Weihong Tan Prof. Dr.

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-846-2410
    2. Biomedical Engineering Center, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China)
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  • We thank the US NIH, China National Scientific Foundation of China (20805038, 20620130427), and National Basic Research Program of China (2007CB935603, 2010CB732402) as well as 2009ZX10004-312 for supporting this work. Z.Z. acknowledges supported by the ACS Division of Analytical Chemistry Fellow sponsored by Procter and Gamble.

Abstract

original image

Cocaine cracked: The gel–sol transition of an enzyme-caged hydrogel has been efficiently controlled by target binding events, which trigger release of the enzyme to take part in its catalytic role for signal amplification (see picture). As low as 20 ng of cocaine can be visually detected within 10 min without any aid of sophisticated instrumentation.

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