These authors contributed equally.
Structures of DNA Polymerases Caught Processing Size-Augmented Nucleotide Probes†
Article first published online: 22 JUN 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 30, pages 5181–5184, July 12, 2010
How to Cite
Betz, K., Streckenbach, F., Schnur, A., Exner, T., Welte, W., Diederichs, K. and Marx, A. (2010), Structures of DNA Polymerases Caught Processing Size-Augmented Nucleotide Probes. Angew. Chem. Int. Ed., 49: 5181–5184. doi: 10.1002/anie.200905724
We gratefully acknowledge funding by the DFG.
- Issue published online: 7 JUL 2010
- Article first published online: 22 JUN 2010
- Manuscript Revised: 5 JAN 2010
- Manuscript Received: 12 OCT 2009
- DNA polymerase;
- DNA replication;
- structure elucidation
The right fit: Synthetic nucleotide analogues are widely used to investigate the mechanisms that govern DNA polymerase selectivity—processes that are crucial for the survival of every living organism. The first crystal structures of size-augmented 4′-methylated and 4′-ethylated thymidine triphosphates (TTPs) in complex with a DNA polymerase have been elucidated (picture: superposition of three DNA polymerase structures in complex with TTPs).