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Keywords:

  • DNA;
  • DNA polymerase;
  • DNA replication;
  • nucleotides;
  • structure elucidation
Thumbnail image of graphical abstract

The right fit: Synthetic nucleotide analogues are widely used to investigate the mechanisms that govern DNA polymerase selectivity—processes that are crucial for the survival of every living organism. The first crystal structures of size-augmented 4′-methylated and 4′-ethylated thymidine triphosphates (TTPs) in complex with a DNA polymerase have been elucidated (picture: superposition of three DNA polymerase structures in complex with TTPs).