Copper-Catalyzed Cross-Coupling of Alkyl and Aryl Grignard Reagents with Alkynyl Halides


  • The authors thank Fondation de France (ESCOM) for a grant to J.B. as well as the Ministère de l’Education Nationale et de la Recherche and the CNRS for financial supports.


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Good old copper! A new general procedure to couple aliphatic and aromatic Grignard reagents with alkynyl halides under copper catalysis is described (see scheme; NMP=N-methylpyrrolidinone). The reaction is chemoselective and allows preparation of a vast array of simple and functionalized internal alkynes in high yields.