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A Highly Sensitive, Excimer-Controlled Molecular Beacon


  • This work was supported financially by the Swiss National Foundation (grant 200020-117617).


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Non-nucleosidic chromophores in the stem of a molecular beacon inhibit excimer fluorescence through the formation of a donor–acceptor complex (see picture). The excellent reduction of the background fluorescence allows the detection of DNA and RNA targets in the presence of a significant excess of the probe.

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