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Keywords:

  • bisphosphonates;
  • immunology;
  • inhibitors;
  • terpenoids
Thumbnail image of graphical abstract

Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use.