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Keywords:

  • asymmetric catalysis;
  • Brønsted acids;
  • cooperative catalysis;
  • organocatalysis;
  • transition metals
Thumbnail image of graphical abstract

Simple and practical: The asymmetric alkynylation of imines has been revolutionized with two nice examples of a novel model of H-bonding asymmetric metal catalysis with Brønsted acids. The catalytic model comprises two well-differentiated and parallel catalytic cycles: one involving metallic alkynylydes (metal catalysis) and the other one using a chiral Brønsted acid (organocatalysis; see scheme; PG=protecting group).