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Copper-Catalyzed Direct Alkenylation of N-Iminopyridinium Ylides


  • This work was supported by the Natural Science and Engineering Research Council of Canada (NSERC), Merck Frosst Canada Ltd., Boehringer Ingelheim (Canada), Ltd., the Canada Research Chairs Program, the Canadian Foundation for Innovation, and the Université de Montréal. J.J.M. is grateful to FQRNT for a postgraduate scholarship.


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A versatile Cu-catalyzed direct C[BOND]H alkenylation of N-iminopyridinium ylides, compatible with several different copper sources (including a penny), provides a powerful and inexpensive method for the synthesis of functionalized pyridine derivatives. Chemoselective functionalization of halide-containing compounds allows the synthesis of alkenyl pyridines containing reactive tethers for further functionalization.