Support from the EPSRC and Merck Research Laboratories is gratefully acknowledged. We thank Adam Zarth and Alexa Sabedra for and preliminary experimental work by. A.M. acknowledges a fellowship from the Fundación Ramón Areces (Spain). D.G.B. is the recipient of a Royal Society Wolfson Research Merit Award. For insight into the allusion to Shakespeare’s Hamlet in the title see reference ‡.
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Essay
The Flow’s the Thing…Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow†
Article first published online: 24 FEB 2010
DOI: 10.1002/anie.200906095
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Valera, Fernando E., Quaranta, M., Moran, A., Blacker, J., Armstrong, A., Cabral, João T. and Blackmond, Donna G. (2010), The Flow’s the Thing…Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow. Angew. Chem. Int. Ed., 49: 2478–2485. doi: 10.1002/anie.200906095
- †
Publication History
- Issue published online: 23 MAR 2010
- Article first published online: 24 FEB 2010
- Manuscript Received: 29 OCT 2009
Funded by
- EPSRC
- Merck Research Laboratories
- Royal Society Wolfson Research Merit Award
Keywords:
- kinetics;
- microreactors;
- organocatalysis;
- reaction mechanisms
Against the flow? What factors dictate the relative merits of microflow reactors versus batch-reaction flasks for homogeneous catalytic reactions? The optimal reaction protocol must be decided on a case-by-case basis. Flask reactors equipped with in situ detection devices provide a concise and information-rich means of obtaining the intrinsic kinetic information required to make this decision.