This work was supported by a Novartis Young Investigator Award. We thank Dr. Michele D’Ambrosio (Università di Trento) for providing us with authentic samples of coralloidolides.
Total Synthesis of Coralloidolides A, B, C, and E†
Article first published online: 9 MAR 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 14, pages 2619–2621, March 29, 2010
How to Cite
Kimbrough, Thomas J., Roethle, Paul A., Mayer, P. and Trauner, D. (2010), Total Synthesis of Coralloidolides A, B, C, and E. Angew. Chem. Int. Ed., 49: 2619–2621. doi: 10.1002/anie.200906126
- Issue published online: 23 MAR 2010
- Article first published online: 9 MAR 2010
- Manuscript Received: 30 OCT 2009
- biomimetic synthesis;
- Lewis acids;
- total synthesis
Mapping the matrix: Several coralloidolides, members of a Mediterranean branch of the furanocembranoid family of diterpenes, have been synthesized. The total syntheses include biomimetic transformations that often occur with high chemoselectivity, thus obviating the need for protecting-group manipulations. The fascinating reactivity of 2,5-diene-1,4-dione moieties was explored in detail.