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Total Synthesis of Coralloidolides A, B, C, and E



This article is corrected by:

  1. Errata: Corrigendum: Total Synthesis of Coralloidolides A, B, C, and E Volume 54, Issue 34, 9743, Article first published online: 13 April 2015

  • This work was supported by a Novartis Young Investigator Award. We thank Dr. Michele D’Ambrosio (Università di Trento) for providing us with authentic samples of coralloidolides.


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Mapping the matrix: Several coralloidolides, members of a Mediterranean branch of the furanocembranoid family of diterpenes, have been synthesized. The total syntheses include biomimetic transformations that often occur with high chemoselectivity, thus obviating the need for protecting-group manipulations. The fascinating reactivity of 2,5-diene-1,4-dione moieties was explored in detail.