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Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae


  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. C.M.P. is particularly grateful for a fellowship from the Danish Agency for Science, Technology and Innovation. We wish to thank B. Wegner, H. Moll, H. Käßner, and Dr. N. Gisch for excellent LTA purification and help in MS and NMR analyses.


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Mixed signals: The glycophospholipid 1, consisting of two cholinylphospho-GalNAc units, two 2-acetamino-4-amino-2,4,6-trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated.