Enantioselective Intermolecular Aldehyde–Ketone Cross-Coupling through an Enzymatic Carboligation Reaction


  • Financial support of this work from the Deutsche Forschungsge-meinschaft, the Landesgraduiertenförderung Baden-Württemberg, and the National Institutes of Health (GM035906) is gratefully acknowledged. We thank F. Bonina for technical support and V. Brecht for NMR spectroscopy.


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Happy new YerE: The first example of the title reaction is presented using a ThDP-dependent enzyme catalyst. The substrate tolerance of the enzyme is very broad and includes cyclic and open-chain ketones, as well as diketones and α- and β-ketoesters as acceptor substrates. The absolute configurations of two enzymatic products were determined by single-crystal structure analysis.