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[Ind2TiMe2]: A Catalyst for the Hydroaminomethylation of Alkenes and Styrenes

Authors

  • Raphael Kubiak,

    1. Institut für Reine und Angewandte Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9–11, 26111 Oldenburg (Germany), Fax: (+49) 441-798-3329
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  • Insa Prochnow,

    1. Institut für Reine und Angewandte Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9–11, 26111 Oldenburg (Germany), Fax: (+49) 441-798-3329
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  • Sven Doye Prof. Dr.

    1. Institut für Reine und Angewandte Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9–11, 26111 Oldenburg (Germany), Fax: (+49) 441-798-3329
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  • We thank the Deutsche Forschungsgemeinschaft (DFG) and the Fonds der Chemischen Industrie for financial support of our research. Ind=η5-indenyl.

Abstract

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Metal-catalyzed hydroaminomethylations of styrenes, which take place by C[BOND]H bond activation, can be achieved in the presence of the catalyst [Ind2TiMe2] (Ind=η5-indenyl). Corresponding reactions of 1-alkenes with N-methylanilines performed at temperatures between 80 °C and 105 °C usually take place with regioselectivities of better than 99:1 in favor of the branched product.

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