Microparticle Matrix Encoding of Beads

Authors


  • This work was supported by the Danish National Research Foundation. We are grateful to D. C. Tvermoes, P. Breddam, P. M. St. Hilaire, R. Michael, and T. Reenberg for support and discussions. T. Schulte-Herbrüggen assisted with the theoretical determination of the encoding potential.

Abstract

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Reloaded matrix: Facile optical encoding of polyethylene glycol (PEG) based resins provides a direct identification of compounds in combinatorial libraries, and the structures may be correlated with bioactivity. The new technique, microparticle matrix (MPM) encoding (see picture), circumvents some problems often encountered in solid-phase combinatorial chemistry and is extremely simple to implement.

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