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Small-Molecule Affinity Ligands for Protein Purification: Combined Computational Enrichment and Automated In-line Screening of an Optically Encoded Library


  • J.E.R. was supported by a PhD stipend from the Danish Ministry of Sciences and Technologies, Versamatrix A/S, and Novo Nordisk A/S (CORA)


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Screening with codes: A versatile methodology for the development of small-molecule affinity chromatography ligands for protein targets is presented. The combination of computational enrichment with automated screening and affinity mapping of an optically encoded combinatorial library allows identification of a novel set of ligands for the single-step purification of human growth hormone (see picture).

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