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Self-Assembled TiO2 Nanocrystal Clusters for Selective Enrichment of Intact Phosphorylated Proteins


  • Y.Y. thanks the University of California, Riverside for start-up funds. Acknowledgement is also given to the Donors of the Petroleum Research Fund, administered by the American Chemical Society, for support of this research. Y.Y. is a Cottrell Scholar of Research Corporation for Science Advancement.


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Mesoporous traps: The title clusters were fabricated through self-assembly of nanocrystals in emulsion droplets and subsequent protective calcination. The specific affinity offered by the metal oxide and the size-exclusion mechanism enabled by the mesoporous structure enable the use of these clusters for efficient enrichment of intact phosphorylated proteins from complex biological samples (see picture).