This work was supported by the National Natural Science Foundation of China (20772093, 20972118, and 20832003), and the Doctoral Fund of the Ministry of Education of China (20060486005).
Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides†
Article first published online: 16 FEB 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 11, pages 2004–2008, March 8, 2010
How to Cite
Liu, W., Cao, H. and Lei, A. (2010), Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides. Angew. Chem. Int. Ed., 49: 2004–2008. doi: 10.1002/anie.200906870
- Issue published online: 3 MAR 2010
- Article first published online: 16 FEB 2010
- Manuscript Received: 6 DEC 2009
- National Natural Science Foundation of China . Grant Numbers: 20772093, 20972118, 20832003
- aryl halides;
- CH activation;
Iron tough: Various aryl halides were treated with unactivated arenes to form biaryl compounds in moderate to good yields. The reactions were carried out at relatively low temperature in the presence of a catalytic amount of FeCl3, with DMEDA as the ligand and LiHMDS as the base (see scheme; DMEDA=N,N'-dimethylethane-1,2-diamine, HDMS=hexamethyldisilazanide).