These authors contributed equally to this paper.
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Total Synthesis of Palau’amine†
Article first published online: 29 DEC 2009
DOI: 10.1002/anie.200907112
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Seiple, Ian B., Su, S., Young, Ian S., Lewis, Chad A., Yamaguchi, J. and Baran, Phil S. (2010), Total Synthesis of Palau’amine. Angew. Chem. Int. Ed., 49: 1095–1098. doi: 10.1002/anie.200907112
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We are grateful to Lars Jørgensen and Dr. Tanja Gaich for technical assistance. We thank Prof. Dr. M. Köck for helpful discussions. Financial support for this work was provided by the NIH/NIGMS (GM-073949), Amgen, Bristol-Myers Squibb (postdoctoral fellowship to S.S.), the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship to J.Y., the Natural Sciences and Engineering Research Council of Canada (NSERC) for a postdoctoral fellowship to I.S.Y., the Canadian Institutes of Health Research (CIHR) for a postdoctoral fellowship to C.A.L., and the NSF for a predoctoral fellowship to I.B.S.
- ‡
These authors contributed equally to this paper.
Publication History
- Issue published online: 26 JAN 2010
- Article first published online: 29 DEC 2009
- Manuscript Received: 17 DEC 2009
Funded by
- NIH/NIGMS. Grant Number: GM-073949
- Amgen
Keywords:
- axinellamines;
- massadine;
- palau’amine;
- total synthesis
Worth the wait: The long anticipated total synthesis of palau'amine has been accomplished by a route featuring highly chemoselective transformations, cascade reactions, and a remarkable transannular cyclization to secure the unprecedented trans-5,5 ring junction (shown in red).