Communication

General and Efficient Copper-Catalyzed Three-Component Coupling Reaction towards Imidazoheterocycles: One-Pot Synthesis of Alpidem and Zolpidem†

  1. Natalia Chernyak,
  2. Vladimir Gevorgyan Prof.

Article first published online: 8 MAR 2010

DOI: 10.1002/anie.200907291

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 49, Issue 15, pages 2743–2746, April 1, 2010

Additional Information

How to Cite

Chernyak, N. and Gevorgyan, V. (2010), General and Efficient Copper-Catalyzed Three-Component Coupling Reaction towards Imidazoheterocycles: One-Pot Synthesis of Alpidem and Zolpidem. Angewandte Chemie International Edition, 49: 2743–2746. doi: 10.1002/anie.200907291

Author Information

  1. Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA), Fax: (+1) 312-355-0836 http://www.chem.uic.edu/vggroup

  1. †

    The support of the NIH (1P50 GM-086145) is gratefully acknowledged.

Publication History

  1. Issue published online: 26 MAR 2010
  2. Article first published online: 8 MAR 2010
  3. Manuscript Received: 26 DEC 2009

Funded by

  • NIH. Grant Number: 1P50 GM-086145

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Keywords:

  • cyclization;
  • heterocycles;
  • homogeneous catalysis;
  • imidazopyridines;
  • multicomponent reactions

Graphical Abstract

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Three is not a crowd: A method for the construction of imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and zolpidem (see scheme).

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