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Enantioselective Kita Oxidative Spirolactonization Catalyzed by In Situ Generated Chiral Hypervalent Iodine(III) Species


  • Financial support for this project was provided by JSPS.KAKENHI (20245022), NEDO, the Shionogi Award in Synthetic Organic Chemistry (Japan), and the Global COE Program of MEXT.


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The iodines(III) have it: The rational design of a conformationally flexible C2-symmetric iodosylarene catalyst has been used for the enantioselective Kita oxidative spirolactonization. The reaction occurs through secondary n–σ* or hydrogen-bonding interactions between the chiral catalyst and the substrate. Mes=mesityl (2,4,6-trimethylphenyl).

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