Total Synthesis of Chondramide C and Its Binding Mode to F-Actin

Authors

  • Herbert Waldmann Prof. Dr.,

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • Tai-Shan Hu Dr.,

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • Steffen Renner Dr.,

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • Sascha Menninger,

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • René Tannert,

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • Toshiro Oda Dr.,

    1. RIKEN, SPring-8 Center, Structural Physiology Research Group, Kouto 1-1-1, Sayo (Japan)
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  • Hans-Dieter Arndt Dr.

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2499
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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Errata

This article corrects:

  1. Total Synthesis of Chondramide C and Its Binding Mode to F-Actin Volume 47, Issue 34, 6473–6477, Article first published online: 15 July 2008

  • This work was supported by the Max Planck Gesellschaft (H.W.), the Deutsche Forschungsgemeinschaft (Emmy-Noether grant to H.D.A.), the state of North-Rhine-Westphalia, and the European Union (ZACG Dortmund). T.S.H. is grateful to the Alexander von Humboldt Stiftung for a research fellowship. We thank Prof. Dr. M. Kalesse for discussions and for making a sample of natural chondramide C available.

In this Communication, one image of the analysis of cellular phenotypes of chondramide C diastereoisomers was wrongly processed (panel C in Figure 1). An improved figure with additional scale bars can be found below. The authors deeply apologize for this oversight and confirm that it does not affect any of the hypothesis or conclusions outlined in the original paper.

Figure 1.

Actin stabilization phenotypes in BSC-1 cells monitored by whole cell fluorescence microscopy (magnification 40×) after staining for actin (red, TRITC-phalloidin, Sigma) and chromatin (blue, DAPI, Sigma); A) DMSO only (negative control); B) 100 nM Jasplakinolide (2, positive control); C) 10 μMZ/E-14 a; D) 5 μMZ-14 b; E) 200 nME-14 c (= 3); F) 10 μME-14 d. TRITC: Tetramethylrhodamin isothiocyanate. Bar: 10 μm.

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