Cover Picture: Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE-43472B (Angew. Chem. Int. Ed. 19/2009)

Authors

  • K. C. Nicolaou Prof. Dr.,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
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  • Yee Hwee Lim,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
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    • These authors contributed equally to this work.

  • Jochen Becker Dr.

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
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    • These authors contributed equally to this work.


Abstract

A cascade sequence featuring a Diels–Alder reaction, a lactolization, and an SN(Ar)-type substitution forms the core of the bisanthraquinone antibiotic BE-43472B in its first total synthesis, which K. C. Nicolaou et al. describe in their Communication on page 3444 ff. The background of the cover picture is a photograph of Ecteinascidia turbinata (courtesy of John Easley Photography), the marine source of the streptomyces strain producing this antibiotic.

original image

A cascade sequence featuring a Diels–Alder reaction, a lactolization, and an SN(Ar)-type substitution forms the core of the bisanthraquinone antibiotic BE-43472B in its first total synthesis, which K. C. Nicolaou et al. describe in their Communication on page 3444 ff. The background of the cover picture is a photograph of Ecteinascidia turbinata (courtesy of John Easley Photography), the marine source of the streptomyces strain producing this antibiotic.

original image

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