BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications

Authors

  • Alistair C. McKinlay,

    1. EaStChem School of Chemistry, University of St Andrews, Purdie Building, St Andrews, KY16 9ST (UK), Fax: (+44) 1334-463-808
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  • Russell E. Morris Prof.,

    1. EaStChem School of Chemistry, University of St Andrews, Purdie Building, St Andrews, KY16 9ST (UK), Fax: (+44) 1334-463-808
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  • Patricia Horcajada Dr.,

    1. Institut Lavoisier, UMR CNRS 8180, Universite de Versailles St Quentin en Yvelines, 45 avenue des Etats-Unis, 78035 Versailles (France), Fax: (+33) 1-3925-4452
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  • Gérard Férey Prof.,

    1. Institut Lavoisier, UMR CNRS 8180, Universite de Versailles St Quentin en Yvelines, 45 avenue des Etats-Unis, 78035 Versailles (France), Fax: (+33) 1-3925-4452
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  • Ruxandra Gref Dr.,

    1. Faculté de Pharmacie (CNRS 8612), Université Paris-Sud, 92296 Châtenay-Malabry (France), 3CNRS 2301, 91190 Gif-sur-Yvette (France) and CNRS8081, Université PARIS-Sud 91405 Orsay (France)
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  • Patrick Couvreur Prof.,

    1. Faculté de Pharmacie (CNRS 8612), Université Paris-Sud, 92296 Châtenay-Malabry (France), 3CNRS 2301, 91190 Gif-sur-Yvette (France) and CNRS8081, Université PARIS-Sud 91405 Orsay (France)
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  • Christian Serre Dr.

    1. Institut Lavoisier, UMR CNRS 8180, Universite de Versailles St Quentin en Yvelines, 45 avenue des Etats-Unis, 78035 Versailles (France), Fax: (+33) 1-3925-4452
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Abstract

The class of highly porous materials called metal–organic frameworks offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, and their high level of functionality enables possible applications as imaging agents and as delivery vehicles for therapeutic agents. The challenges in the area encompass not only the development of new solids but also improvements in the formulation and processing of the materials, including tailoring the morphology and surface chemistry of the frameworks to fit the proposed applications.

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