Communication

Photothermal Effects of Supramolecularly Assembled Gold Nanoparticles for the Targeted Treatment of Cancer Cells†

  1. Shutao Wang Dr.1,
  2. Kuan-Ju Chen1,
  3. Ting-Hsiang Wu3,
  4. Hao Wang Dr.1,
  5. Wei-Yu Lin Dr.1,
  6. Minori Ohashi1,
  7. Pei-Yu Chiou Prof.2,
  8. Hsian-Rong Tseng Prof.1

Article first published online: 9 APR 2010

DOI: 10.1002/anie.201000062

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 49, Issue 22, pages 3777–3781, May 17, 2010

Additional Information

How to Cite

Wang, S., Chen, K.-J., Wu, T.-H., Wang, H., Lin, W.-Y., Ohashi, M., Chiou, P.-Y. and Tseng, H.-R. (2010), Photothermal Effects of Supramolecularly Assembled Gold Nanoparticles for the Targeted Treatment of Cancer Cells. Angew. Chem. Int. Ed., 49: 3777–3781. doi: 10.1002/anie.201000062

Author Information

  1. 1

    Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA), Fax: (+1) 310-206-8975 http://labs.pharmacology.ucla.edu/tsenglab/

  2. 2

    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 420 Westwood Plaza, EIV 37-138, Los Angeles, CA 90095 (USA)

  3. 3

    Department of Electrical Engineering, University of California, Los Angeles, 420 Westwood Plaza, EIV 37-138, Los Angeles, CA 90095 (USA)

  1. †

    This research was supported by NIH-NCI NanoSystems Biology Cancer Center (U54CA119347).

Publication History

  1. Issue published online: 10 MAY 2010
  2. Article first published online: 9 APR 2010
  3. Manuscript Received: 6 JAN 2010

Funded by

  • NIH
  • NCI. Grant Number: U54CA119347

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Keywords:

  • gold;
  • nanoparticles;
  • photothermal effects;
  • self-assembly;
  • tumor therapy
Thumbnail image of graphical abstract

Laser-triggered nanobomb: Size-controlled gold supramolecular nanoparticles (Au-SNPs) were synthesized from 2 nm gold colloids by a supramolecular self-assembly approach. These Au-SNPs exhibited significantly enhanced photothermal effects and could be used in conjunction with laser irradiation for the selective destruction of cancer cells (see picture) after the incorporation of a target-specific ligand.

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