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One-Pot Synthesis of Biomimetic Shell Cross-Linked Micelles and Nanocages by ATRP in Alcohol/Water Mixtures


  • S.S. thanks the JSPS Postdoctoral Fellowships for a Research Abroad grant. A sample of 2-(methacryloyloxy)ethyl phosphorylcholine was kindly donated by Biocompatibles Ltd. (Farnham, UK). ATRP=atom transfer radical polymerization.


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Shell shock: The one-pot synthesis of shell cross-linked (SCL) micelles was achieved using an ABC triblock copolymer in a 9:1 alcohol/water mixture. These SCL micelles were dialyzed against water, leading to solvation of the core-forming PMPC chains. If the cross-linking is not too high, these chains migrate through the inner shell to join the coronal PEO chains, hence forming nanocages.

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