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Halomethane Biosynthesis: Structure of a SAM-Dependent Halide Methyltransferase from Arabidopsis thaliana

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  • We thank the BBSRC for a grant (BB/F007426/1) and J.W.S. thanks the Wellcome Trust for the Value in People (VIP) Scheme for financial support. SAM=S-adenosyl-L-methionine.

Abstract

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It's a gas! The structure of the halomethane-producing halo/thiocyanate methyltransferase enzyme from plants has been determined. The halide ion and the methyl group of S-adenosyl-L-methionine (SAM) were modeled into the active site (see picture; chloride: green sphere; SAM: C green, O red, S yellow, N blue), which indicated their predisposition for reaction.

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