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Keywords:

  • biosensors;
  • cyanines;
  • fluorescent probes;
  • G-quadruplexes;
  • peptide nucleic acids
Thumbnail image of graphical abstract

A healthy glow: Fluorogenic peptide nucleic acids (PNAs) functionalized with indoline derivatives are used to specifically sense G-quadruplex formation. Upon hybridization of both PNAs to the single-stranded flanking arms of quadruplex DNA (see scheme), the synthesis of a trimethine cyanine dye is templated. Dye formation can be detected by the appearance of a characteristic fluorescence signal.