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Rhodium-Catalyzed Cascade Reaction: Aryl Addition/Intramolecular Esterification to Access 3-Aryl and 3-Alkenyl Phthalides


  • We thank the National Natural Science Foundation of China (No. 20972115), the Key Project of Chinese Ministry of Education (No. 209054), and the State Key Laboratory of Coordination Chemistry of Nanjing University for financial support.


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First one and then the other: A rhodium-catalyzed addition of aryl and alkenyl boronic acids to phthalaldehyde and subsequent intramolecular esterification is described (see scheme; cod=1,5-cyclooctadiene, dppb=1,4-bis(diphenylphosphino)butane). The method is facile and practical for accessing 3-aryl and 3-alkenyl phthalides in moderate to good yields. Several functional groups are tolerated under the reaction conditions.

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