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Keywords:

  • glycopeptides;
  • ligation;
  • peptide thioesters;
  • synthetic methods
Thumbnail image of graphical abstract

Going native: A mercaptomethyl group on the side-chain hydroxy group of serine and threonine residues facilitates a native chemical ligation reaction at the Xaa-Ser/Thr site (see scheme; R=H or Me). The intermediate thioester is treated to achieve an S- to N-acyl shift. After ligation, the group is spontaneously removed to obtain the glycopeptide contulakin-G and human calcitonin.