Get access

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2


  • This work was supported by the Deutsche Forschungsgemeinschaft, the Jürgen Knop-Stiftung, and the Chinesisch-Deutsches Zentrum für Wissenschaftsförderung, Beijing, program number GZ561. Toll-like receptors are receptors that resemble the protein coded by the Toll gene; they are also known as pattern recognition receptors.


original image

Fragment condensation of a protected Pam3Cys lipopeptide with unprotected tumor-associated MUC1 glycopeptides opens the way to vaccine candidates such as A. These vaccines elicit selective immune responses in mice although they lack an immunodominant carrier protein. In principle, such vaccines are applicable to humans.

Get access to the full text of this article