Sonogashira Cross-Coupling of Arenediazonium Salts


  • We gratefully acknowledge GlaxoSmithKline for their generous financial support and a fellowship position as well as Dr. Alcide Perboni and Dr. Paolo Stabile of GlaxoSmithKline for valuable discussions. We are also indebted to MURST and to La Sapienza, University of Rome.


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Star-crossed lovers: The domino iododediazoniation/Sonogashira cross-coupling of terminal alkynes with arenediazonium salts has been developed. The arenediazonium salt synthesis/iododediazoniation/Sonogashira cross-coupling sequence can also be performed as a one-pot process, omitting the isolation of the arenediazonium salt.