Sonogashira Cross-Coupling of Arenediazonium Salts

Authors


  • We gratefully acknowledge GlaxoSmithKline for their generous financial support and a fellowship position as well as Dr. Alcide Perboni and Dr. Paolo Stabile of GlaxoSmithKline for valuable discussions. We are also indebted to MURST and to La Sapienza, University of Rome.

Abstract

original image

Star-crossed lovers: The domino iododediazoniation/Sonogashira cross-coupling of terminal alkynes with arenediazonium salts has been developed. The arenediazonium salt synthesis/iododediazoniation/Sonogashira cross-coupling sequence can also be performed as a one-pot process, omitting the isolation of the arenediazonium salt.

Ancillary