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Cover Picture: The Catalytic Asymmetric Knoevenagel Condensation (Angew. Chem. Int. Ed. 7/2011)

Authors

  • Anna Lee,

    1. Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2982
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  • Dr. Anna Michrowska,

    1. Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2982
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  • Dr. Sarah Sulzer-Mosse,

    1. Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2982
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  • Prof. Dr. Benjamin List

    Corresponding author
    1. Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2982
    • Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2982
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Abstract

original image

The annual rings of the pictured tree represent the time gap, 116 years, between the discovery of the Knoevenagel condensation and that of the first catalytic asymmetric variant. As described by B. List et al. in their Communication on page 1707 ff., a cinchona amine catalyst promotes the reaction of α-branched aldehydes and malonates through a dynamic kinetic resolution to give alkylidene malonates with high enantioselectivity.

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