These authors contributed equally to the article.
Molecular Recognition of a Transition State†
Article first published online: 28 MAY 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 28, pages 4816–4819, June 28, 2010
How to Cite
Bao, X., Rieth, S., Stojanović, S., Hadad, Christopher M. and Badjić, Jovica D. (2010), Molecular Recognition of a Transition State. Angew. Chem. Int. Ed., 49: 4816–4819. doi: 10.1002/anie.201000656
This work was financially supported with funds obtained from the Ohio State University and the National Science Foundation under CHE-0716355. Generous computational resources were provided by the Ohio Supercomputer Center.
- Issue published online: 21 JUN 2010
- Article first published online: 28 MAY 2010
- Manuscript Received: 3 FEB 2010
- Ohio State University
- National Science Foundation. Grant Number: CHE-0716355
- host–guest systems;
- molecular dynamics;
- molecular recognition;
- supramolecular catalysis;
- transition states
An inside job: The conformational interconversion of cyclohexane occurs at a higher rate in the interior of gated molecular baskets (see picture) than in bulk free solvent or a vacuum. The acceleration results from more favorable noncovalent bonding, and hence stabilization of the transition state, of the encapsulated compound.