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Cross-Coupling Reactions through the Intramolecular Activation of Alkyl(triorgano)silanes


  • This work was supported financially by a Grant-in-Aid for Creative Scientific Research and Priority Areas “Synergy of Elements” from MEXT.


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Cross-Si-ing the Jordan: Cross-coupling reactions of 2-(2-hydroxyprop-2-yl)phenyl-substituted alkylsilanes with a variety of aryl halides proceed in the presence of palladium and copper catalysts. The use of K3PO4 base allows for highly chemoselective alkyl coupling with both primary and secondary alkyl groups (Alk).

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